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Jatrorrhizine chloride

CAS No. 6681-15-8

Jatrorrhizine chloride ( Neprotine chloride;Yatrorhizine chloride )

Catalog No. M21537 CAS No. 6681-15-8

Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 104 In Stock
50MG 160 In Stock
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Biological Information

  • Product Name
    Jatrorrhizine chloride
  • Note
    Research use only not for human use.
  • Brief Description
    Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
  • Description
    Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
  • Synonyms
    Neprotine chloride;Yatrorhizine chloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    OCT; PMAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6681-15-8
  • Formula Weight
    373.8
  • Molecular Formula
    C20H20ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (13.38 mM)
  • SMILES
    COc(ccc1cc(-c(cc2OC)c(CC3)cc2O)[n+]3cc11)c1OC.[Cl-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sun S et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.
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